One of the very useful cases where you would want to use RegionKing is when you setup your lighting with HDR Images. As you can not have a live view of your results when using PhysicalRender or Vray you need to wait for any small change of the HDRI orientation or any other change.
With RegionKing you can make this process a lot easier. You change HDRI Images and make variations of the orientation and send everything with a single click to the Renderqueue. While you still setup your variations you already get results to compare. When you have choosen the best rendering you just Rightclick in the Renderqueue to open the File. It is so easy and fast and especially if you need many variations to compare this is a great workflow.